The westbound I-44 to southbound Highway 65 (Exit 82A) ramp in Springfield will close at 11:30 Wednesday night and re-open at 1:30 a.m. Thursday.
MoDOT says contractor crews are closing the ramp to repair a guardrail.
I-44 and Highway 65 will remain open while the ramp is closed.
Drivers are urged to find alternate routes.
Electronic message boards located near the planned road work will alert drivers to any changes in the work schedule.